SB 525334

SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.

Product Specifications

CAS Number

[356559-20-1]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H413

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SB-525334.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(C1=NC(C2=CC=CC(C)=N2)=C(C3=CC=C4N=CC=NC4=C3)N1)C

Molecular Formula

C21H21N5

Molecular Weight

343.42

Precautions

H301, H315, H319, H335, H413

References & Citations

[1]Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313 (3), 943-951.|[2]Thomas M, et al. ALK5 mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol, 2009, 174 (2), 380-389.|[3]Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13 (10), 3087-3899.