Ku70 Mouse Monoclonal Antibody [D1-A6]
Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.
Product Specifications
Product Name Alternative
Abbreviation
5'-dRP lyase Ku70,CTC75,CTCBF,Ku70,TLAA
Swiss Prot
P12956 Human, P23475 mouse
Cellular Locus
Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within human Ku70 aa 1-150/609.
Isotype
IgG2a
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:100-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 70 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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