Ku70 Mouse Monoclonal Antibody [D1-A6]

Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

5'-deoxyribose-5-phosphate lyase Ku70 antibody 5'-dRP lyase Ku70 antibody 70 kDa subunit of Ku antigen antibody ATP dependent DNA helicase 2 subunit 1 antibody ATP dependent DNA helicase II 70 kDa subunit antibody ATP-dependent DNA helicase 2 subunit 1 antibody ATP-dependent DNA helicase II 70 kDa subunit antibody CTC box binding factor 75 kDa subunit antibody CTC box-binding factor 75 kDa subunit antibody CTC75 antibody CTCBF antibody DNA repair protein XRCC6 antibody G22P1 antibody Ku 70 antibody Ku autoantigen p70 subunit antibody Ku autoantigen, 70kDa antibody Ku p70 antibody Ku70 antibody Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody Kup70 antibody Lupus Ku autoantigen protein p70 antibody ML8 antibody Thyroid autoantigen 70kD (Ku antigen) antibody Thyroid autoantigen antibody Thyroid lupus autoantigen antibody Thyroid lupus autoantigen p70 antibody Thyroid-lupus autoantigen antibody TLAA antibody X ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair complementing defective repair in Chinese hamster cells 6 antibody X-ray repair cross-complementing protein 6 antibody XRCC 6 antibody Xrcc6 antibody XRCC6_HUMAN antibody

Abbreviation

5'-dRP lyase Ku70,CTC75,CTCBF,Ku70,TLAA

Swiss Prot

P12956 Human, P23475 mouse

Cellular Locus

Nucleus.

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

Recombinant protein within human Ku70 aa 1-150/609.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysates, HepG2 cell lysates, A431 cell lysates, D3 cell lysates, 293T cell lysates, A549 cell lysates, COS-1 cell lysates, human kidney tissue lysates, human liver tissue lysates, human brain tissue lysates, human thymus tissue lysates, human placentae tissue lysates, mouse kidney tissue lysates, mouse liver tissue lysates, mouse thymus tissue lysates, mouse testis tissue lysates, human tonsil tissue,human breast cancer tissue.