SIRP alpha Mouse Monoclonal Antibody [A3E3]

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Signal regulatory protein alpha type 1 antibody Bit antibody Brain Ig like molecule with tyrosine based activation motifs antibody Brain Ig-like molecule with tyrosine-based activation motifs antibody Brain immunoglobulin like molecule with tyrosine based activation motifs antibody CD172 antigen like family member A antibody CD172 antigen-like family member A antibody CD172a antibody CD172a antigen antibody Inhibitory receptor SHPS-1 antibody Macrophage fusion receptor antibody MFR antibody MYD 1 antibody Myd 1 antigen antibody MyD-1 antigen antibody p84 antibody Protein tyrosine phosphatase non receptor type substrate 1 antibody PTPNS1 antibody SHP substrate 1 antibody SHPS-1 antibody SHPS1 antibody SHPS1_HUMAN antibody Signal regulatory protein alpha 2 antibody Signal regulatory protein alpha 3 antibody Signal regulatory protein alpha antibody Signal regulatory protein alpha type 2 antibody Signal-regulatory protein alpha-1 antibody Signal-regulatory protein alpha-2 antibody Signal-regulatory protein alpha-3 antibody SIRP antibody Sirp-alpha-1 antibody Sirp-alpha-2 antibody Sirp-alpha-3 antibody SIRPA antibody SIRPalpha antibody SIRPalpha1 antibody SIRPalpha2 antibody SIRPalpha3 antibody Tyrosine phosphatase SHP substrate 1 antibody Tyrosine protein phosphatase non receptor type substrate 1 antibody Tyrosine-protein phosphatase non-receptor type substrate 1 antibody

Abbreviation

Tyrosine-protein phosphatase non-receptor type substrate 1 SHP substrate 1 SHPS-1 Brain Ig-like molecule with tyrosine-based activation motifs Bit CD172 antigen-like family member A Inhibitory receptor SHPS-1 Macrophage fusion receptor MyD-1 antigen Signal-regulatory protein alpha-1 Sirp-alpha-1 Signal-regulatory protein alpha-2 Sirp-alpha-2 Signal-regulatory protein alpha-3 Sirp-alpha-3 p84 CD172a SIRPA

Swiss Prot

P78324 Human

Cellular Locus

Membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human SIRP alpha aa 1-400.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

SW480 cell lysates, THP-1, human lung cancer tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500 ;IF-Cell:1:50 ;IHC-P:1:50-1:200 ;FC:1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 55 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Curated Selection

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