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CD11b Mouse Monoclonal Antibody [A2-B5-D2]

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development .

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

antigen CD11b (p170) antibody Antigen CD11b p170 antibody CD11 antigen like family member B antibody CD11 antigen-like family member B antibody CD11b antibody CD11b/CD18 antibody CD49d antibody Cell surface glycoprotein MAC-1 subunit alpha antibody Complement component 3 receptor 3 subunit antibody Complement Component Receptor 3 Alpha antibody Complement receptor type 3 antibody Complement receptor type 3, alpha subunit antibody CR 3 alpha chain (CR3A) antibody CR 3 alpha chain antibody CR-3 alpha chain antibody CR3 antibody CR3A antibody F730045J24Rik antibody Integrin Alpha M antibody Integrin alpha M chain antibody Integrin alpha-M antibody Integrin beta 2 alpha subunit antibody Integrin subunit alpha M antibody integrin, alpha M (complement component 3 receptor 3 subunit) antibody ITAM_HUMAN antibody ITGAM antibody Leukocyte adhesion receptor MO1 antibody Ly-40 antibody MAC 1 antibody Mac-1a antibody MAC1 antibody Mac1, alpha subunit antibody MAC1A antibody Macrophage antigen alpha polypeptide antibody MGC117044 antibody Mo1 antibody Mo1, alpha subunit antibody MO1A antibody Neutrophil adherence receptor alpha M subunit antibody Neutrophil adherence receptor antibody SLEB6 antibody

Abbreviation

Integrin alpha-M,CD11 antigen-like family member B,CR-3 alpha chain.Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,CD11b,Itgam

Swiss Prot

P11215 Human, P05555 Mouse

Cellular Locus

Cell membrane, Membrane.

Host

Mouse

Species Reactivity

Human,Mouse

Immunogen

Recombinant protein within mouse CD11b aa 1-300.

Isotype

IgM

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB

Positive Control

RAW264.7 cell lysates, Mouse spleen tissue lysates, A549.

Concentration

2 mg/mL

Dilution

WB: 1:500

Purity

Protein A/G affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 127 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No

Frequently Asked Questions

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