CEACAM6 Mouse Monoclonal Antibody [A1E2]
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion. Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
CEACAM6
Swiss Prot
P40199 Human
Cellular Locus
Cell membrane, apical cell membrane, cell surface.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within Human CEACAM6 aa 1-160 / 344.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
SK-Br-3 cell lysate, A549 cell lysate, human colon tissue, human colon cancer tissue, A549, HT-29, MCF-7, SW620.
Concentration
2 mg/mL
Dilution
WB:1:1,000-1:2,000 ;IF-Cell:1:50-1:100 ;IHC-P:1:50-1:400 ;FC:1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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