NM23 Mouse Monoclonal Antibody [13C2]
Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
NDK A NDP kinase A GAAD NME1 NDPKA NM23
Swiss Prot
P15531 Human, P15532 Mouse, Q05982 Rat
Cellular Locus
Cytoplasm, Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human NM23 aa 10-30.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;IHC-P: 1:2,000 ;IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 17 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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