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NQO1 Mouse Monoclonal Antibody [13A1]

NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals and radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression and coordinated induction of NQO1. ARE activation by tert-butylhydroquinone is dependent on PI3-kinase, which lies upstream of Nrf2. Nrf2, c-Jun, Nrf1, Jun-B and Jun-D bind to the ARE and regulate expression and induction of NQO1 gene. Maf-Maf homodimers and possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE and do not repress NQO1 transcription.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Azoreductase antibody Cytochrome b 5 reductase antibody DHQU antibody DIA 4 antibody DIA4 antibody Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) antibody Diaphorase (NADH/NADPH) antibody Diaphorase 4 antibody Dioxin inducible 1 antibody DT diaphorase antibody DT-diaphorase antibody DTD antibody Menadione reductase antibody NAD (P)H dehydrogenase [quinone] 1 antibody NAD (P)H dehydrogenase quinone 1 antibody NAD (P)H menadione oxidoreductase 1 dioxin inducible antibody NAD (P)H quinone dehydrogenase 1 antibody NAD (P)H: menadione oxidoreductase 1 dioxin inducible 1 antibody NAD (P)H:menadione oxidoreductase 1 antibody NAD (P)H:Quinone acceptor oxidoreductase type 1 antibody NAD (P)H:quinone oxidoreductase 1 antibody NAD (P)H:quinone oxireductase antibody NMOR 1 antibody NMOR I antibody NMOR1 antibody NMORI antibody NQO 1 antibody NQO1 antibody NQO1_HUMAN antibody Phylloquinone reductase antibody QR 1 antibody QR1 antibody Quinone reductase 1 antibody

Abbreviation

DTD, QR1, NQO1, DIA4, NMOR1

Swiss Prot

P15559 Human, P05982 Rat

Cellular Locus

Cytoplasm.

Host

Mouse

Species Reactivity

Human,Rat

Immunogen

Recombinant protein within Human NQO1 aa 1-274 / 274.

Isotype

IgG2b

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB

Positive Control

A549 cell lysate, SiHa cell lysate, HepG2 cell lysate, MCF7 cell lysate, HeLa cell lysate.

Concentration

2 mg/mL

Dilution

WB: 1:2,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 31 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No

Frequently Asked Questions

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