IMP3 Mouse Monoclonal Antibody [4-C2-5]
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
IGF2 mRNA-binding protein 3, IMP-3, hKOC, IGF2BP3, IMP3, KOC1, VICKZ3
Swiss Prot
O00425 Human, Q9CPN8 Mouse,
Cellular Locus
Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human IMP3 aa 350-579.
Isotype
IgG
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, FC
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:2,000 ;FC: 1:50-1:100
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 64 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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