Bcl-2 Mouse Monoclonal Antibody [9F3]
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Apoptosis regulator Bcl-2
Swiss Prot
P10415 Human
Cellular Locus
Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane, Cytoplasm.
Host
Mouse
Species Reactivity
Human
Immunogen
Synthetic peptide within human BCL2 aa 30-80.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
THP-1 cell lysate, HL-60 cell lysate, human tonsil tissue, human b-cell lymphoma tissue, THP-1.
Concentration
2 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:500-1:2,000 ;FC: 1:1,000
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 26 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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