PTBP1 Mouse Monoclonal Antibody [9A1]
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
PTB, hnRNP I, PTBP1, PTB
Swiss Prot
P26599 Human, Q00438 Rat
Cellular Locus
Nucleus.
Host
Mouse
Species Reactivity
Human,Rat
Immunogen
Recombinant protein within human PTBP1 aa 320-550.
Isotype
IgG2a
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
Concentration
2 mg/mL
Dilution
WB: 1:5,000-1:10,000;IHC-P: 1:50-1:100;IF-Cell: 1:50-1:100;FC: 1:50-1:100
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 57 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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