Smad2 Mouse Monoclonal Antibody [C9-B0]
Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
MAD homolog 2, Mothers against DPP homolog 2, hMAD-2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2
Swiss Prot
Q15796 Human, Q62432 Mouse, O70436 Rat
Cellular Locus
Cytoplasm. Nucleus.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human Smad2 aa 151-450 / 467.
Isotype
IgG1
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Hela, A549, HUVEC, rat testis tissue, human tonsil tissue, human liver cancer tissue, mouse brain tissue.
Concentration
2 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
58 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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