CD11b Mouse Monoclonal Antibody [4-6]
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
ITGAM, CD11B, CR3A
Swiss Prot
P11215 Human
Cellular Locus
Cell membrane.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within Human CD11b aa 544-743 / 1,152.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
IHC-P, IF-Cell, FC, WB
Positive Control
TF-1 cell lysate, THP-1 cell lysate, U-937 cell lysate, A431, LOVO, human tonsil tissue, human spleen tissue.
Concentration
2 mg/mL
Dilution
IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC:1:50-1:100 ;WB: 1:1,000
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 127 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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