GRB2 Mouse Monoclonal Antibody [11-B11]
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
GRB2, ASH
Swiss Prot
P62993 Human, Q60631 Mouse, P62994 Rat
Cellular Locus
Endosome, Nucleus, Golgi apparatus, Cytoplasm.
Host
Mouse
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human GRB2 aa 21-217 / 217.
Isotype
IgG2b
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
293T cell lysate, A431 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse testis tissue, rat testis tissue, rat brain tissue, MCF-7, HepG2.
Concentration
2 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200
Purity
Protein G affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 25 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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