EpCAM Mouse Monoclonal Antibody [3-E1-E2]
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies. Mutations in EpCAM have also been associated with congenital tufting enteropathy which causes intractable diarrhea in newborn children.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Ep-CAM,EGP,EGP314,hEGP314
Swiss Prot
P16422 Human, Q99JW5 Mouse
Cellular Locus
Cell membrane
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within human EP-CAM aa 24-265 (Extracellular).
Isotype
IgM
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IF-Cell
Positive Control
Hela cell lysate, NIH/3T3 cell lysate, MCF-7 cell lysate, D3, A431.
Concentration
2 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:100-1:200
Purity
Protein L affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 35 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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