Frizzled-5 Rabbit Polyclonal Antibody
Frizzled-5 belongs to the G-protein coupled receptor Fz/Smo family, contains 585 amino acids. It is localized at the plasma membrane and also found at the Golgi. Fzds have a large extracellular N-terminal region containing a cysteine-rich domain (CRD), which is involved in binding to Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Fz-5,hFz5
Swiss Prot
Q13467 Human
Cellular Locus
Cell membrane.Golgi apparatus. Membrane. Synapse.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Frizzled-5 aa 143-192 / 585.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Human ES cell, A549, LOVO, HepG2.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000;IF-Cell:1:50-1:200;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 64 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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