Carcino Embryonic Antigen CEA Rabbit Polyclonal Antibody
The CD66 (carcinoembryonic antigen, CEA, biliary glycoprotein I, BGP-1, CEACAM) immunoglobulin superfamily of genes encode cell adhesion proteins, which are expressed at higher levels in tumorous tissues than in normal tissues. The human CD66 gene family is a diverse set of glycoproteins of epithelial and hematopoietic lineage that comprises 29 genes, which map to chromosome position 19q13.1-q13.2. CD66A, CD66B, CD66C, CD66D, CD66E and CD66F are the best characterized CD66 antigens, and CD66A-D expression upregulates on the surface of granulocytes upon stimulation. Certain CD66 family members mediate homotypic and heterotypic intercellular adhesion events. CD66E, also known as CEA, is a well known tumor marker and a heavily glycosylated GPI-linked cell surface molecule.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
CEA
Swiss Prot
P06731 Human
Cellular Locus
Cell membrane, Membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human CEA aa 153-216.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
MCF-7 cell lysate, SK-Br-3, SW620, human liver cancer tissue, human colon cancer tissue, HepG2.
Concentration
1 mg/mL
Dilution
WB:1:1,000-1:2,000;IF-Cell:1:50-1:200;IHC-P:1:50-1:200;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 77 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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