JJC8-088

JJC8-088, a Modafinil-derived ligand, is a dopamine transporter (DAT) inhibitor with a Ki of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders[1][2].

Product Specifications

CAS Number

[1627576-82-2]

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jjc8-088.html

Solubility

10 mM in DMSO

Smiles

O=S(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)CCN3CCN(CC3)CC(CC4=CC=CC=C4)O

Molecular Formula

C28H32F2N2O2S

Molecular Weight

498.63

References & Citations

[1]Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103. |[2]Newman AH, et al. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44 (8) :1435-1444.