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Tropolone

Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos (t) ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma[1][2][3][4].

Product Specifications

CAS Number

533-75-5

UNSPSC

12352005

Hazard Statement

H314, H317, H410

Target

Fungal; Tyrosinase

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tropolone.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : ≥ 100 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

O=C1C(O)=CC=CC=C1

Molecular Formula

C7H6O2

Molecular Weight

122.12

Precautions

H314, H317, H410

References & Citations

[1]Donald D Nolting, et al. Synthesis of bicyclo[5.3.0]azulene derivatives. Nat Protoc. 2009; 4 (8) : 1113–1117.|[2]VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908|[3]Woodson ME, et al. In vitro evaluation of tropolone absorption, metabolism, and clearance. Antiviral Res. 2023 Dec;220:105762.|[4]Haney SL, et al. Investigation of the activity of a novel tropolone in osteosarcoma. Drug Dev Res. 2024 Feb;85 (1) :e22129.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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