Hedgehog IN-7
Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer[1].
Product Specifications
UNSPSC
12352005
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hedgehog-in-7.html
Smiles
N#CC1=CC=C(C2=C3N=CN(CC4CC4)C3=NC(NC5=CC=C(N6CCN(C)CC6)C(F)=C5)=N2)C=C1
Molecular Formula
C27H27FN8
Molecular Weight
482.56
References & Citations
[1]Espinosa-Bustos C, et al. New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer[J]. Bioorganic Chemistry, 2024, 151: 107681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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