Hedgehog IN-7

Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards the Hedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer[1].

Product Specifications

UNSPSC

12352005

Target

Hedgehog

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hedgehog-in-7.html

Smiles

N#CC1=CC=C(C2=C3N=CN(CC4CC4)C3=NC(NC5=CC=C(N6CCN(C)CC6)C(F)=C5)=N2)C=C1

Molecular Formula

C27H27FN8

Molecular Weight

482.56

References & Citations

[1]Espinosa-Bustos C, et al. New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer[J]. Bioorganic Chemistry, 2024, 151: 107681.