JTC-801 (free base)

JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2 nM.

Product Specifications

CAS Number

[244218-93-7]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jtc-801-free-base.html

Smiles

O=C(C1=CC=CC=C1COC2=CC=C(C=C2)CC)NC3=CC=C4N=C(C=C(C4=C3)N)C

Molecular Formula

C26H25N3O2

Molecular Weight

411.50

References & Citations

[1]Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23 (2) :301-3.|[2]Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL (1) ) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135 (2), 323-332.|[3]Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43 (24), 4667-4677.|[4]Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172 (2) :571-82.