GPX4-IN-12
GPX4-IN-12 (compound I22) is a non-covalent GPX4 inhibitor. GPX4-IN-12 induces ferroptosis and inhibits cell growth of HT1080 cells[1].
Product Specifications
CAS Number
[931704-14-2]
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-12.html
Smiles
N#CC1=C(NCCCN2C=CN=C2)OC(C3=CC=C(O3)COC4=CC=CC=C4)=N1
Molecular Formula
C21H19N5O3
Molecular Weight
389.41
References & Citations
[1]Huang W, et al. Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. Eur J Med Chem. 2024 Jul 10;276:116670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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