Perfluorodecanoic acid

Perfluorodecanoic acid (PFDA) is a perfluoroalkyl substance (PFAS) . Perfluorodecanoic acid induces weight loss and increases liver weight and lipid content in mice. Perfluorodecanoic acid also reduces mRNA expression of the genes encoding IL-1β, IL-18, and cellular inhibitor of apoptosis 2 (cIAP2), as well as caspase-1, -3, and -7 in mouse liver[1][2].

Product Specifications

CAS Number

[335-76-2]

Product Name Alternative

PFDA

UNSPSC

12352211

Hazard Statement

H301, H351, H360, H362

Target

Caspase; Interleukin Related

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

98.21

Solubility

DMSO : 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

C(=O)(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O

Molecular Formula

C10HF19O2

Molecular Weight

514.08

Precautions

H301, H351, H360, H362

References & Citations

[1]Olson CT, et al. The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids. Toxicol Appl Pharmacol. 1983 Sep 30;70 (3) :362-72. |[2]Harris MW, et al. Developmental toxicity of perfluorodecanoic acid in C57BL/6N mice. Fundam Appl Toxicol. 1989 Apr;12 (3) :442-8.