Antileishmanial agent-26

Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC50 value against Leishmania donovani is 5.67 μM, and its CC50 value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-26.html

Solubility

10 mM in DMSO

Smiles

COC1=CC2=C(N(C)C)N=C(NCC3=CC=C(F)C=C3)N=C2C=C1OC4CCCC4

Molecular Formula

C23H27FN4O2

Molecular Weight

410.48

References & Citations

[1]Das N, et al. Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani[J]. European Journal of Medicinal Chemistry, 2024: 116256.