AMC-04
AMC-04 is an unfolded protein response (UPR) activator, which activates UPR pathway through ROS and p38 MAPK signaling and induces apoptotic cell death. AMC-04 can be used for cancer research[1].
Product Specifications
CAS Number
[792928-94-0]
UNSPSC
12352005
Target
P38 MAPK; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amc-04.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(CC2=CC(OC)=CC=C2OC)CC1)C3=CC=C(C4=CC=CC=C4)C=C3
Molecular Formula
C26H28N2O3
Molecular Weight
416.51
References & Citations
[1]Kim SY, et al. Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. Chem Biol Interact. 2020 Dec 1;332:109277.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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