AMC-04

AMC-04 is an unfolded protein response (UPR) activator, which activates UPR pathway through ROS and p38 MAPK signaling and induces apoptotic cell death. AMC-04 can be used for cancer research[1].

Product Specifications

CAS Number

[792928-94-0]

UNSPSC

12352005

Target

P38 MAPK; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amc-04.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(CC2=CC(OC)=CC=C2OC)CC1)C3=CC=C(C4=CC=CC=C4)C=C3

Molecular Formula

C26H28N2O3

Molecular Weight

416.51

References & Citations

[1]Kim SY, et al. Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. Chem Biol Interact. 2020 Dec 1;332:109277.