GW695634
GW695634 is an orally active prodrug of GW678248. GW695634 undergoes amidolysis in vivo to release the active ingredient GW678248, thereby inhibiting viral replication. GW678248 is a non-nucleoside reverse transcriptase inhibitor (NNRTi) with potent antiviral activity against Efavirenz -resistant and Nevirapine (HY-10570) -resistant HIV and AIDS viruses[1].
Product Specifications
CAS Number
457635-65-3
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gw695634.html
Smiles
CCC(NS(=O)(C1=CC=C(C(C)=C1)NC(COC2=CC=C(C=C2C(C3=CC(C#N)=CC(Cl)=C3)=O)Cl)=O)=O)=O
Molecular Formula
C26H21Cl2N3O6S
Molecular Weight
574.43
References & Citations
[1]M de Serres, et al. "The disposition and metabolism of GW695634: a non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS." Xenobiotica 40.6 (2010) : 437-445.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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