Amyloid 17-42
Amyloid 17-42 (Aβ (17-42) ) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP) . Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].
Product Specifications
CAS Number
155178-13-5
Product Name Alternative
Aβ (17-42)
UNSPSC
12352209
Target
Apoptosis
Type
Peptides
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amyloid-17-42.html
Solubility
10 mM in DMSO
Smiles
OC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CNC(CNC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](CC(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC(CNC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@@H](N)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C119H194N28O33S
Molecular Weight
2577.05
References & Citations
[1]Wanli Wei, et al. Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis. Brain. 2002 Sep;125 (Pt 9) :2036-43.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FI111715-01 2000 mg
DL-2,3-Isopropylideneglycerylmethyl resin (200-400 mesh)
Sign In for Pricing
View Details FI111715-02 5000 mg
DL-2,3-Isopropylideneglycerylmethyl resin (200-400 mesh)
Sign In for Pricing
View Details FI111715-03 10000 mg
DL-2,3-Isopropylideneglycerylmethyl resin (200-400 mesh)
Sign In for Pricing
View Details