NLRP3-IN-44
NLRP3-IN-44 (compound P33) is a potent and orally active (approximately 62%) inhibitor of NLRP3, with the Kd of 17.5 nM. NLRP3-IN-44 plays an important for studying NLRP3 inflammasome-mediated diseases[1].
Product Specifications
CAS Number
3040298-34-5
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-44.html
Smiles
OC1=C(C(N=NC(N[C@H]2CN(CCC2)CCO)=C34)=C3C5CCC4CC5)C=CC6=C1C=CO6
Molecular Formula
C25H30N4O3
Molecular Weight
434.53
References & Citations
[1]Zhiyuan Fu, et al. Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis. J Med Chem. 2024 Sep 12;67 (17) :15711-15737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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