AZD8330
AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.
Product Specifications
CAS Number
[869357-68-6]
Product Name Alternative
ARRY-424704; ARRY-704
UNSPSC
12352005
Hazard Statement
H301, H372
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD8330.html
Purity
99.06
Solubility
DMSO : ≥ 100 mg/mL
Smiles
IC1=CC(F)=C(C=C1)NC(N2C)=C(C=C(C2=O)C)C(NOCCO)=O
Molecular Formula
C16H17FIN3O4
Molecular Weight
461.23
Precautions
H301, H372
References & Citations
[1]Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49 (7) :1521-9.|[2]Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6 (11-12) :503-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MEK1; MEK2
Available Sizes
Curated Selection
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