GSK-3β inhibitor 1
GSK-3β inhibitor 1 (compound 3a) inhibits GSK-3β with an IC50 of 4.19 nM. GSK-3β inhibitor 1 demonstrates high antidiabetic efficacy in obese Streptozotocin (HY-13753) -treated rats[1].
Product Specifications
CAS Number
[187325-53-7]
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3-beta-inhibitor-1.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2/C1=C/C3=NC=CC=C3
Molecular Formula
C14H10N2O
Molecular Weight
222.25
References & Citations
[1]Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27 (9) :1804-1817.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Available Sizes
Curated Selection
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