Sarafotoxin S6a (TFA)

Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204) . Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

Product Specifications

UNSPSC

12352209

Target

Endothelin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sarafotoxin-s6a-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC3=CN=CN3)[C@H]4NC([C@H](CC5=CC=CC=C5)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@]6(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@]([H])([C@@H](C)O)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@@]([H])(NC([C@H](CO)NC([C@@H](N)CSSC4)=O)=O)CSSC6)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O)=O

Molecular Formula

C105H156N28O34S5.xC2HF3O2

Molecular Weight

2514.85 (free acid)

References & Citations

[1]P Schoeffter, et al. Differences between endothelin receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur J Pharmacol

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

ETA; ETB

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS691576-01 0.005 mg

Human TFF-2

Ask

View Details

MBS691576-02 0.02 mg

Human TFF-2

Ask

View Details

MBS691576-03 5x 0.02 mg

Human TFF-2

Ask

View Details

CN-01994R2 48T

Rat C-Peptide ELISA Kit

Ask

View Details

44323064 1.0 µg DNA

Slco1a5 Lentiviral Vector (Mouse) (CMV) (pLenti-GIII-CMV)

Ask

View Details