π-TRTX-Hm3a

π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM[1].

Product Specifications

UNSPSC

12352209

Target

Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/π-trtx-hm3a.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@H]2CCC(O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@@H](C)CC)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCC(O)=O)C(N[C@H]%10C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%11=CNC=N%11)C(NCC(N[C@@H](CC(O)=O)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C(C)C)C(N%12[C@@H](CCC%12)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

Molecular Formula

C186H290N56O49S6

Molecular Weight

4287.03

References & Citations

[1]Sing Yan Er, et al. Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology. 2017 Dec:127:185-195.