Mirvetuximab soravtansine (solution)
Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage[1].
Product Specifications
CAS Number
1453084-37-1
Product Name Alternative
IMGN853 (solution)
UNSPSC
12352211
Target
Antibody-Drug Conjugates (ADCs) ; Antifolate
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mirvetuximab-soravtansine-solution.html
Purity
98.20
Solubility
10 mM in DMSO
Smiles
[Mirvetuximabsoravtansine(solution)]
Molecular Formula
C6482H10006N1714O2022S44 (C42H58ClN3O14S3) n
Molecular Weight
150000 (average)
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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