2R,4R-Sacubitril
2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
Product Specifications
CAS Number
766480-48-2
UNSPSC
12352005
Hazard Statement
H336-H372
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2R,4R-Sacubitril.html
Purity
98.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]N(C(CCC(O)=O)=O)[C@@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@H](C(OCC)=O)C
Molecular Formula
C24H29NO5
Molecular Weight
411.49
Precautions
P260-P261-P264-P270-P271-P304+P340-P403+P233-P405-P501
References & Citations
[1]Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44 (4) :554-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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