N6-Methyladenine

N6-Methyladenine is a DNA epigenetic modification that involves the addition of a methyl group to the sixth position of adenine. N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases[1][2].

Product Specifications

CAS Number

[443-72-1]

UNSPSC

12352005

Hazard Statement

H314

Target

DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n6-methyladenine.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CNC1=C2NC=NC2=NC=N1

Molecular Formula

C6H7N5

Molecular Weight

149.16

Precautions

H314

References & Citations

[1]Hao Li, et al. DNA N6-Methyladenine Modification in Eukaryotic Genome. Front Genet. 2022 Jun 24:13:914404. |[2]Luan J, et al. N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases. Kidney Int Rep. 2022 Oct 17;8 (1) :36-50.