MAGL-IN-16
MAGL-IN-16 (compound 27) is an oral active, selective and reversible MAGL inhibitor with the IC50 value of 10.3 nM. MAGL-IN-16 can increase the level of 2-AG and shows antidepressant effect in mouse depressed model caused by chronic restraint stress[1].
Product Specifications
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/magl-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C2=CC=C(C3=CC=C(Cl)C=C3)C=N2)CC1)C4=CC=C(C=CC(N5)=O)C5=C4
Molecular Formula
C25H21ClN4O2
Molecular Weight
444.91
References & Citations
[1]Hao Q, et al. Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression. Eur J Med Chem. 2024 Feb 26;268:116285.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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