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MAGL-IN-16

MAGL-IN-16 (compound 27) is an oral active, selective and reversible MAGL inhibitor with the IC50 value of 10.3 nM. MAGL-IN-16 can increase the level of 2-AG and shows antidepressant effect in mouse depressed model caused by chronic restraint stress[1].

Product Specifications

UNSPSC

12352005

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/magl-in-16.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(C2=CC=C(C3=CC=C(Cl)C=C3)C=N2)CC1)C4=CC=C(C=CC(N5)=O)C5=C4

Molecular Formula

C25H21ClN4O2

Molecular Weight

444.91

References & Citations

[1]Hao Q, et al. Discovery of a novel class of reversible monoacylglycerol lipase inhibitors for potential treatment of depression. Eur J Med Chem. 2024 Feb 26;268:116285.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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