Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (MALS verified)

Rat NKG2A&CD94 Protein, Mouse IgG2a Fc Tag (NC4-R5258) is expressed from human 293 cells (HEK293) . It contains AA Thr 90 - Asn 231 (NKG2A) & Lys 32 - Thr 179 (CD94) (Accession # O54872-1 (NKG2A) & O35778-1 (CD94) ) .

Product Specifications

Background

CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA) -E on target cells.

Specifications

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 61.0 kDa. The protein migrates as 67-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

O54872-1 (NKG2A) & O35778-1 (CD94)

Expression Region

Thr 90 - Asn 231 (NKG2A) & Lys 32 - Thr 179 (CD94)

Host

HEK293

Target

NKG2A & CD94

Conjugation

Unconjugated

Tag

C-mFc (mIgG2a)

Source

Rat

Stability

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.