NF-κB-IN-16
Product Specifications
UNSPSC Description
NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-κB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models[1].
Target Antigen
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-16.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]([NH3])(Cl)(Cl)([NH3])Cl)=O)=O)=C2)OC)=O)=C1)OC
Molecular Weight
837.01
References & Citations
[1]Wang M, et al. Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance. J Med Chem. 2024 Apr 25;67(8):6218-6237.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158156/NF-κB-IN-16-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158156/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
