Elevenostat
Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes[1][2].
Product Specifications
CAS Number
1454902-97-6
Product Name Alternative
JB3-22
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
Apoptosis; Caspase; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/elevenostat.html
Purity
95.07
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1
Molecular Formula
C16H17N3O4
Molecular Weight
315.32
Precautions
H228, H315, H319
References & Citations
[1]Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6 (24) :e151713. Published 2021 Dec 22. |[2]Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7 (1) :8626. Published 2017 Aug 17. |[3]Sui L, et al. HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation. Cell Cycle. 2020 Feb;19 (3) :354-362.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; HDAC11
Available Sizes
Frequently Asked Questions
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