Elevenostat

Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes[1][2].

Product Specifications

CAS Number

[1454902-97-6]

Product Name Alternative

JB3-22

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

Apoptosis; Caspase; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elevenostat.html

Purity

95.07

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1

Molecular Formula

C16H17N3O4

Molecular Weight

315.32

Precautions

H228, H315, H319

References & Citations

[1]Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6 (24) :e151713. Published 2021 Dec 22. |[2]Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7 (1) :8626. Published 2017 Aug 17. |[3]Sui L, et al. HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation. Cell Cycle. 2020 Feb;19 (3) :354-362.