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Nav1.8-IN-5

Nav1.8-IN-5 (Example 1) is a voltage-gated sodium channel Nav1.8 inhibitor. Nav1.8-IN-5 can be used for Nav1.8-mediated diseases, such as pain and pain-related disorders, as well as cardiovascular diseases (such as atrial fibrillation) research[1].

Product Specifications

CAS Number

[3023247-79-9]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nav1-8-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C1)NC2=C1N3CN(C4=CC=C(F)C=C4C/C=C/2)C5=CC=C(C(F)(F)F)C=C5C3=O

Molecular Formula

C23H15F4N3O2

Molecular Weight

441.38

References & Citations

[1]Jie GUANG, et al. Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors. Patent WO2023238065A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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