Nav1.8-IN-5
Nav1.8-IN-5 (Example 1) is a voltage-gated sodium channel Nav1.8 inhibitor. Nav1.8-IN-5 can be used for Nav1.8-mediated diseases, such as pain and pain-related disorders, as well as cardiovascular diseases (such as atrial fibrillation) research[1].
Product Specifications
CAS Number
[3023247-79-9]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nav1-8-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C1)NC2=C1N3CN(C4=CC=C(F)C=C4C/C=C/2)C5=CC=C(C(F)(F)F)C=C5C3=O
Molecular Formula
C23H15F4N3O2
Molecular Weight
441.38
References & Citations
[1]Jie GUANG, et al. Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors. Patent WO2023238065A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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