3-Aminobenzoic acid

3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects[1][2][3][4].

Product Specifications

CAS Number

[99-05-8]

Product Name Alternative

M-Aminobenzoic acid; 3ABA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-aminobenzoic-acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=CC(C(O)=O)=CC=C1

Molecular Formula

C7H7NO2

Molecular Weight

137.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Tanaka M, et al. Exploring 3-Aminobenzoic Acid as a Therapeutic Dietary Component for Enhancing Intestinal Barrier Integrity in Ulcerative Colitis[J]. bioRxiv, 2024: 2024.08. 18.608525.|[2]Tanaka M, et al. P095 Accelerated degradation of gut barrier-protecting 3-aminobenzoic acid exacerbate colitis in Inflammatory Bowel Disease[J]. Journal of Crohn's and Colitis, 2024, 18 (Supplement_1) : i374-i374.|[3]Kumar A, et al. 3-Aminobenzoic Acid Analogues as a Novel GABA-at Inhibitors: Synthesis, Pharmacological Evaluation and Molecular Docking Studies[J]. Drug Discovery and Development, 2014, 1 (2) : 110-120.