Dihydrorhodamine 6G

Dihydrorhodamine 6G (DHR 6G) is the reduced form of Rhodamine 6G, which is used as fluorescent mitochondrial dye. It is nonfluorescent, but it readily enters most of the cells and is oxidized by oxidative species or by cellular redox systems to the fluorescent rhodamine 6G that accumulates in mitochondrial membranes. Dihydrorhodamine 6G is useful for detecting reactive oxygen species (ROS) including superoxide[1].

Product Specifications

CAS Number

[217176-83-5]

Product Name Alternative

DHR 6G

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dihydrorhodamine-6g.html

Purity

98.17

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OCC)C1=CC=CC=C1C2C3=C(OC4=C2C=C(C)C(NCC)=C4)C=C(NCC)C(C)=C3

Molecular Formula

C28H32N2O3

Molecular Weight

444.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Yong Qin, et al. Dihydrorhodamine 123 is superior to 2,7-dichlorodihydrofluorescein diacetate and dihydrorhodamine 6G in detecting intracellular hydrogen peroxide in tumor cells. Cell Biol Int. 2008 Feb;32 (2) :224-8.