Ipatasertib (tosylate)
Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models[1][2].
Product Specifications
CAS Number
1491138-24-9
Product Name Alternative
GDC-0068 (tosylate) ; RG7440 (tosylate)
UNSPSC
12352005
Target
Akt; Apoptosis; Organoid
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipatasertib-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.ClC2=CC=C([C@@H](CNC(C)C)C(N3CCN(C4=C([C@H](C)C[C@H]5O)C5=NC=N4)CC3)=O)C=C2
Molecular Formula
C31H40ClN5O5S
Molecular Weight
630.20
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Akt1; Akt2; Akt3
Frequently Asked Questions
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