JMV 3002
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.
Product Specifications
CAS Number
925239-03-8
UNSPSC
12352005
Hazard Statement
H225-H319-H336
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/jmv-3002.html
Smiles
O=C(C1=NC=CC=C1)N[C@@H](C2=NN=C(CCC3=CC=CC=C3)N2CC4=CC=C(OC)C=C4OC)CC5=CNC6=C5C=CC=C6
Molecular Formula
C35H34N6O3
Molecular Weight
586.68
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Granulocyte Marker (BM-1), CF640R conjugate, 0.1mg/mL
trans-Clopenthixol-d4 (-)-10-Camphorsulfonic Acid Salt
EGFR (Epidermal Growth Factor Receptor) (rGFR/1667), CF647 conjugate, 0.1mg/mL
