SDM-8

SDM-8 is a difluoro-analog of UCB-J (HY-136873) .SDM-8 shows high SV2A binding affinity with a Ki of 0.58 nM. SDM-8 can be used in the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[2242777-37-1]

UNSPSC

12352005

Target

Radionuclide-Drug Conjugates (RDCs)

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sdm-8.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C[C@H](C2=CC(F)=CC(F)=C2)CN1CC3=CC=NC=C3C

Molecular Formula

C17H16F2N2O

Molecular Weight

302.32

References & Citations

[1]Li S, et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1544-1554.